The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

We identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone (1) , a compound in clinical trials for anti-fibrotic and anti-inflammatory applications (2) , as a potent inhibitor of SARS-CoV-2 infection and replication. The interaction of SARS-CoV-2 spike protein with cell surface heparan sulf...

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Udgivet i:bioRxiv
Main Authors: Sandoval, Daniel R., Clausen, Thomas Mandel, Nora, Chelsea, Cribbs, Adam P., Denardo, Andrea, Clark, Alex E., Garretson, Aaron F., Coker, Joanna K.C., Narayanan, Anoop, Majowicz, Sydney A., Philpott, Martin, Johansson, Catrine, Dunford, James E., Spliid, Charlotte B., Golden, Gregory J., Payne, N. Connor, Tye, Mark A., Nowell, Cameron J., Griffis, Eric R., Piermatteo, Ann, Grunddal, Kaare V., Alle, Thibault, Magida, Jason A., Hauser, Blake M., Feldman, Jared, Caradonna, Timothy M., Pu, Yuan, Yin, Xin, McVicar, Rachael N., Kwong, Elizabeth M., Weiss, Ryan J., Downes, Michael, Tsimikas, Sotirios, Smidt, Aaron G., Ballatore, Carlo, Zengler, Karsten, Evans, Ron M., Chanda, Sumit K., Croker, Ben A., Leibel, Sandra L., Jose, Joyce, Mazitschek, Ralph, Oppermann, Udo, Esko, Jeffrey D., Carlin, Aaron F., Gordts, Philip L.S.M.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010724/
https://ncbi.nlm.nih.gov/pubmed/33791697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.22.436522
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