The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

We identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone (1) , a compound in clinical trials for anti-fibrotic and anti-inflammatory applications (2) , as a potent inhibitor of SARS-CoV-2 infection and replication. The interaction of SARS-CoV-2 spike protein with cell surface heparan sulf...

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Publicado no:bioRxiv
Main Authors: Sandoval, Daniel R., Clausen, Thomas Mandel, Nora, Chelsea, Cribbs, Adam P., Denardo, Andrea, Clark, Alex E., Garretson, Aaron F., Coker, Joanna K.C., Narayanan, Anoop, Majowicz, Sydney A., Philpott, Martin, Johansson, Catrine, Dunford, James E., Spliid, Charlotte B., Golden, Gregory J., Payne, N. Connor, Tye, Mark A., Nowell, Cameron J., Griffis, Eric R., Piermatteo, Ann, Grunddal, Kaare V., Alle, Thibault, Magida, Jason A., Hauser, Blake M., Feldman, Jared, Caradonna, Timothy M., Pu, Yuan, Yin, Xin, McVicar, Rachael N., Kwong, Elizabeth M., Weiss, Ryan J., Downes, Michael, Tsimikas, Sotirios, Smidt, Aaron G., Ballatore, Carlo, Zengler, Karsten, Evans, Ron M., Chanda, Sumit K., Croker, Ben A., Leibel, Sandra L., Jose, Joyce, Mazitschek, Ralph, Oppermann, Udo, Esko, Jeffrey D., Carlin, Aaron F., Gordts, Philip L.S.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010724/
https://ncbi.nlm.nih.gov/pubmed/33791697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.22.436522
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