Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity

Dopamine transporter (DAT) mediates the reuptake of synaptically released dopamine, and thus controls the duration and intensity of dopamine neurotransmission. Mammalian DAT has been observed to form oligomers, although the mechanisms of oligomerization and its role in DAT activity and trafficking r...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Sorkina, Tatiana, Cheng, Mary Hongying, Bagalkot, Tarique R., Wallace, Callen, Watkins, Simon C., Bahar, Ivet, Sorkin, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010718/
https://ncbi.nlm.nih.gov/pubmed/33610553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100430
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