Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity

Dopamine transporter (DAT) mediates the reuptake of synaptically released dopamine, and thus controls the duration and intensity of dopamine neurotransmission. Mammalian DAT has been observed to form oligomers, although the mechanisms of oligomerization and its role in DAT activity and trafficking r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sorkina, Tatiana, Cheng, Mary Hongying, Bagalkot, Tarique R., Wallace, Callen, Watkins, Simon C., Bahar, Ivet, Sorkin, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010718/
https://ncbi.nlm.nih.gov/pubmed/33610553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100430
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