In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway

The disulfide isomerase ERp57, originally found in the endoplasmic reticulum, is located in multiple cellular compartments, participates in diverse cell functions and interacts with a huge network of binding partners. It was recently suggested as an attractive new target for cancer therapy due to it...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Ocklenburg, Tobias, Neumann, Fabian, Wolf, Alexandra, Vogel, Julia, Göpelt, Kirsten, Baumann, Melanie, Baumann, Jennifer, Kranz, Philip, Metzen, Eric, Brockmeier, Ulf
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009878/
https://ncbi.nlm.nih.gov/pubmed/33785835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86658-5
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