Verifying the Role of 3-Hydroxy of 17-Cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4′-pyridyl) carboxamido]morphinan Derivatives via Their Binding Affinity and Selectivity Profiles on Opioid Receptors

In the present study, the role of 3-hydroxy group of a series of epoxymorphinan derivatives in their binding affinity and selectivity profiles toward the opioid receptors (ORs) has been investigated. It was found that the 3-hydroxy group was crucial for the binding affinity of these derivatives for...

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Publicat a:Bioorg Chem
Autors principals: Huang, Boshi, Gunta, Rama, Wang, Huiqun, Li, Mengchu, Cao, Danni, Mendez, Rolando E., Gillespie, James C., Chen, Chongguang, Huang, Lan-Hsuan Melody, Liu-Chen, Lee-Yuan, Selley, Dana E., Zhang, Yan
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009840/
https://ncbi.nlm.nih.gov/pubmed/33631465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2021.104702
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