(19)F- and (18)F-Arene Deoxyfluorination via Organic Photoredox-Catalysed Polarity-Reversed Nucleophilic Aromatic Substitution

Nucleophilic aromatic substitution (S(N)Ar) is routinely used to install (19)F(−) and (18)F(−) in aromatic molecules, but is typically limited to electron-deficient arenes due to kinetic barriers associated with C–F bond formation. Here we demonstrate that a polarity-reversed photoredox-catalysed ar...

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Bibliographic Details
Published in:Nat Catal
Main Authors: Tay, Nicholas E. S., Chen, Wei, Levens, Alison, Pistritto, Vincent A., Huang, Zeng, Wu, Zhanhong, Li, Zibo, Nicewicz, David A.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009013/
https://ncbi.nlm.nih.gov/pubmed/33791591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41929-020-0495-0
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