Direct arene C-H fluorination with (18)F(−) via organic photoredox catalysis

Positron emission tomography (PET) plays key roles in drug discovery and development, as well as medical imaging. However, there is a dearth of efficient and simple radiolabeling methods for aromatic C–H bonds, which limits advancements in PET radiotracer development. Here, we disclose a mild method...

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Bibliographic Details
Published in:Science
Main Authors: Chen, Wei, Huang, Zeng, Tay, Nicholas E. S., Giglio, Benjamin, Wang, Mengzhe, Wang, Hui, Wu, Zhanhong, Nicewicz, David A., Li, Zibo
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680023/
https://ncbi.nlm.nih.gov/pubmed/31221856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7019
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