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The hexadehydro-Diels-Alder reaction: Benzyne generation via cycloisomerization of tethered triynes

The hexadehydro-Diels-Alder (HDDA) reaction is the thermal cyclization of an alkyne and a 1,3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a variety of species to yield highly functionalized benzenoid products. In contrast to nearly all other methods of aryne g...

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Dettagli Bibliografici
Pubblicato in:Chem Rev
Autori principali: Fluegel, Lucas L., Hoye, Thomas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008985/
https://ncbi.nlm.nih.gov/pubmed/33492939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.0c00825
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