Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design

[Image: see text] The Mg(2+)-dependent Mycobacterium tuberculosis salicylate synthase (MbtI) is a key enzyme involved in the biosynthesis of siderophores. Because iron is essential for the survival and pathogenicity of the microorganism, this protein constitutes an attractive target for antitubercul...

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Foilsithe in:J Med Chem
Main Authors: Mori, Matteo, Stelitano, Giovanni, Gelain, Arianna, Pini, Elena, Chiarelli, Laurent R., Sammartino, José C., Poli, Giulio, Tuccinardi, Tiziano, Beretta, Giangiacomo, Porta, Alessio, Bellinzoni, Marco, Villa, Stefania, Meneghetti, Fiorella
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2020
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008425/
https://ncbi.nlm.nih.gov/pubmed/32530281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00373
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