New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

Tuberculosis is the leading cause of death from a single infectious agent worldwide; therefore, the need for new antitubercular drugs is desperate. The recently validated target salicylate synthase MbtI is the first enzyme involved in the biosynthesis of mycobactins, compounds able to chelate iron,...

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Pini, Elena, Poli, Giulio, Tuccinardi, Tiziano, Chiarelli, Laurent Roberto, Mori, Matteo, Gelain, Arianna, Costantino, Luca, Villa, Stefania, Meneghetti, Fiorella, Barlocco, Daniela
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099841/
https://ncbi.nlm.nih.gov/pubmed/29933627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071506
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