New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

Tuberculosis is the leading cause of death from a single infectious agent worldwide; therefore, the need for new antitubercular drugs is desperate. The recently validated target salicylate synthase MbtI is the first enzyme involved in the biosynthesis of mycobactins, compounds able to chelate iron,...

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Detalhes bibliográficos
Main Authors: Elena Pini, Giulio Poli, Tiziano Tuccinardi, Laurent Roberto Chiarelli, Matteo Mori, Arianna Gelain, Luca Costantino, Stefania Villa, Fiorella Meneghetti, Daniela Barlocco
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-06-01
Colecção:Molecules
Assuntos:
antimycobacterial agent
siderophore
mycobactin
iron
consensus docking
chorismate
MD simulation
Acesso em linha:http://www.mdpi.com/1420-3049/23/7/1506
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