UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy

p62/SQSTM1 is known to act as a key mediator in the selective autophagy of protein aggregates, or aggrephagy, by steering ubiquitinated protein aggregates towards the autophagy pathway. Here, we use a yeast two-hybrid screen to identify the prefoldin-like chaperone UXT as an interacting protein of p...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Yoon, Min Ji, Choi, Boyoon, Kim, Eun Jin, Ohk, Jiyeon, Yang, Chansik, Choi, Yeon-Gil, Lee, Jinyoung, Kang, Chanhee, Song, Hyun Kyu, Kim, Yoon Ki, Woo, Jae-Sung, Cho, Yongcheol, Choi, Eui-Ju, Jung, Hosung, Kim, Chungho
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007730/
https://ncbi.nlm.nih.gov/pubmed/33782410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22252-7
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