Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1

Protein aggregation can induce explicit neurotoxic events that trigger a number of presently untreatable neurodegenerative disorders. Chaperones, on the other hand, play a neuroprotective role because of their ability to unfold and refold abnormal proteins. The progressive nature of neurotoxic event...

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Publicado en:J Neurosci
Autores principales: Akber, Uroos, Jo, Heeji, Jeon, Seungje, Yang, Seung-Joo, Bong, Sunhwa, Lim, Sungsu, Kim, Yun Kyung, Park, Zee-Yong, Park, Chul-Seung
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2021
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211538/
https://ncbi.nlm.nih.gov/pubmed/33972400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2494-20.2021
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