Expanding the scope of plant genome engineering with Cas12a orthologs and highly multiplexable editing systems

CRISPR-Cas12a is a promising genome editing system for targeting AT-rich genomic regions. Comprehensive genome engineering requires simultaneous targeting of multiple genes at defined locations. Here, to expand the targeting scope of Cas12a, we screen nine Cas12a orthologs that have not been demonst...

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發表在:Nat Commun
Main Authors: Zhang, Yingxiao, Ren, Qiurong, Tang, Xu, Liu, Shishi, Malzahn, Aimee A., Zhou, Jianping, Wang, Jiaheng, Yin, Desuo, Pan, Changtian, Yuan, Mingzhu, Huang, Lan, Yang, Han, Zhao, Yuxin, Fang, Qing, Zheng, Xuelian, Tian, Li, Cheng, Yanhao, Le, Ysa, McCoy, Bailey, Franklin, Lidiya, Selengut, Jeremy D., Mount, Stephen M., Que, Qiudeng, Zhang, Yong, Qi, Yiping
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007695/
https://ncbi.nlm.nih.gov/pubmed/33782402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22330-w
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