Expanding the scope of plant genome engineering with Cas12a orthologs and highly multiplexable editing systems

CRISPR-Cas12a is a promising genome editing system for targeting AT-rich genomic regions. Comprehensive genome engineering requires simultaneous targeting of multiple genes at defined locations. Here, to expand the targeting scope of Cas12a, we screen nine Cas12a orthologs that have not been demonst...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Zhang, Yingxiao, Ren, Qiurong, Tang, Xu, Liu, Shishi, Malzahn, Aimee A., Zhou, Jianping, Wang, Jiaheng, Yin, Desuo, Pan, Changtian, Yuan, Mingzhu, Huang, Lan, Yang, Han, Zhao, Yuxin, Fang, Qing, Zheng, Xuelian, Tian, Li, Cheng, Yanhao, Le, Ysa, McCoy, Bailey, Franklin, Lidiya, Selengut, Jeremy D., Mount, Stephen M., Que, Qiudeng, Zhang, Yong, Qi, Yiping
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007695/
https://ncbi.nlm.nih.gov/pubmed/33782402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22330-w
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