Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently based on recruitment of either intracellular m...

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Bibliographische Detailangaben
Veröffentlicht in:Molecules
Hauptverfasser: Staroseletz, Yaroslav, Gaponova, Svetlana, Patutina, Olga, Bichenkova, Elena, Amirloo, Bahareh, Heyman, Thomas, Chiglintseva, Daria, Zenkova, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8003597/
https://ncbi.nlm.nih.gov/pubmed/33808835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26061732
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