Site-Selective Artificial Ribonucleases: Oligonucleotide Conjugates Containing Multiple Imidazole Residues in the Catalytic Domain

Design of site-selective artificial ribonucleases (aRNases) is one of the most challenging tasks in RNA targeting. Here, we designed and studied oligonucleotide-based aRNases containing multiple imidazole residues in the catalytic part and systematically varied structure of cleaving constructs. We d...

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Autori principali: Beloglazova, Natalia G., Fabani, Martin M., Polushin, Nikolai N., Sil'nikov, Vladimir V., Vlassov, Valentin V., Bichenkova, Elena V., Zenkova, Marina A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE-Hindawi Access to Research 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180074/
https://ncbi.nlm.nih.gov/pubmed/21961054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/748632
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