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Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. miRNases comprise a peptide [(LeuArg)(2)Gly](2) capa...
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| I publikationen: | Front Pharmacol |
|---|---|
| Huvudupphovsmän: | , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Frontiers Media S.A.
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6698794/ https://ncbi.nlm.nih.gov/pubmed/31456683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00879 |
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