Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. miRNases comprise a peptide [(LeuArg)(2)Gly](2) capa...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Patutina, Olga A., Miroshnichenko, Svetlana K., Mironova, Nadezhda L., Sen’kova, Aleksandra V., Bichenkova, Elena V., Clarke, David J., Vlassov, Valentin V., Zenkova, Marina A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698794/
https://ncbi.nlm.nih.gov/pubmed/31456683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00879
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