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Exons and introns exhibit transcriptional strand asymmetry of dinucleotide distribution, damage formation and DNA repair

Recent cancer sequencing efforts have uncovered asymmetry in DNA damage induced mutagenesis between the transcribed and non-transcribed strands of genes. Here, we investigate the major type of damage induced by ultraviolet (UV) radiation, the cyclobutane pyrimidine dimers (CPDs), which are formed pr...

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Détails bibliographiques
Publié dans:NAR Genom Bioinform
Auteurs principaux: Heilbrun, Elisheva E, Merav, May, Adar, Sheera
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8002178/
https://ncbi.nlm.nih.gov/pubmed/33817640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nargab/lqab020
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