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Medically Important Alterations in Transport Function and Trafficking of ABCG2

Several polymorphisms and mutations in the human ABCG2 multidrug transporter result in reduced plasma membrane expression and/or diminished transport function. Since ABCG2 plays a pivotal role in uric acid clearance, its malfunction may lead to hyperuricemia and gout. On the other hand, ABCG2 residi...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Autor Principal: Homolya, László
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8001156/
https://ncbi.nlm.nih.gov/pubmed/33801813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062786
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