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Medically Important Alterations in Transport Function and Trafficking of ABCG2
Several polymorphisms and mutations in the human ABCG2 multidrug transporter result in reduced plasma membrane expression and/or diminished transport function. Since ABCG2 plays a pivotal role in uric acid clearance, its malfunction may lead to hyperuricemia and gout. On the other hand, ABCG2 residi...
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| Veröffentlicht in: | Int J Mol Sci |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8001156/ https://ncbi.nlm.nih.gov/pubmed/33801813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062786 |
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