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Identification of Specific Trafficking Defects of Naturally Occurring Variants of the Human ABCG2 Transporter
Proper targeting of the urate and xenobiotic transporter ATP-binding transporter subfamily G member 2 (ABCG2) to the plasma membrane (PM) is essential for its normal function. The naturally occurring Q141K and M71V polymorphisms in ABCG2, associated with gout and hyperuricemia, affect the cellular r...
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| 發表在: | Front Cell Dev Biol |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Frontiers Media S.A.
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7900420/ https://ncbi.nlm.nih.gov/pubmed/33634118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.615729 |
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