The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers

Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer...

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Pubblicato in:Pharmaceutics
Autori principali: Lee, Jong-Hwa, Jeong, Hyeong Sik, Jeong, Jong-Woo, Koo, Tae-Sung, Kim, Do-Kyun, Cho, Young Ho, Lee, Gye Won
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8001048/
https://ncbi.nlm.nih.gov/pubmed/33800741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13030344
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