Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan

Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility. In this study, we enhanced the solubility, bioavailability, and stability of TEL through the fabrication of TEL-loaded pH-modulated solid dispe...

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發表在:Pharmaceuticals (Basel)
Main Authors: Giri, Bhupendra Raj, Kwon, Jaewook, Vo, Anh Q., Bhagurkar, Ajinkya M., Bandari, Suresh, Kim, Dong Wuk
格式: Artigo
語言:Inglês
出版: MDPI 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7831136/
https://ncbi.nlm.nih.gov/pubmed/33477557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14010073
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