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Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

Meprin α and β are zinc-dependent proteinases implicated in multiple diseases including cancers, fibrosis, and Alzheimer’s. However, until recently, only a few inhibitors of either meprin were reported and no inhibitors are in preclinical development. Moreover, inhibitors of other metzincins develop...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Pharmaceuticals (Basel)
Päätekijät: Hou, Shurong, Diez, Juan, Wang, Chao, Becker-Pauly, Christoph, Fields, Gregg B., Bannister, Thomas, Spicer, Timothy P., Scampavia, Louis D., Minond, Dmitriy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000592/
https://ncbi.nlm.nih.gov/pubmed/33671080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14030203
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