Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function

Inflammasomes sense a number of pathogen and host damage signals to initiate a signaling cascade that triggers inflammatory cell death, termed pyroptosis. The inflammatory caspases (1/4/5/11) are the key effectors of this process through cleavage and activation of the pore-forming protein gasdermin...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Davies, Christopher W., Stowe, Irma, Phung, Qui T., Ho, Hoangdung, Bakalarski, Corey E., Gupta, Aaron, Zhang, Yingnan, Lill, Jennie R., Payandeh, Jian, Kayagaki, Nobuhiko, Koerber, James T.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000503/
https://ncbi.nlm.nih.gov/pubmed/33723046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018024118
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