Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors

The K(+)-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a cell-surface mediator of matrix degradation and t...

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Foilsithe in:Int J Mol Sci
Main Authors: Buckley, Benjamin J., Kumar, Ashna, Aboelela, Ashraf, Bujaroski, Richard S., Li, Xiuju, Majed, Hiwa, Fliegel, Larry, Ranson, Marie, Kelso, Michael J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2021
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000185/
https://ncbi.nlm.nih.gov/pubmed/33804289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062999
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