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B-Raf Associates with and Activates the NHE1 Isoform of the Na(+)/H(+) Exchanger
The serine/threonine kinase B-Raf is the second most frequently occurring human oncogene after Ras. Mutations of B-Raf occur with the highest incidences in melanoma, and the most common mutant, V600E, renders B-Raf constitutively active. The sodium proton exchanger isoform 1 (NHE1) is a ubiquitously...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075656/ https://ncbi.nlm.nih.gov/pubmed/21345796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165134 |
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