Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment. During a fractionated radiation regimen, these hy...

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Опубликовано в: :Cells
Главные авторы: Menegakis, Apostolos, Klompmaker, Rob, Vennin, Claire, Arbusà, Aina, Damen, Maartje, van den Broek, Bram, Zips, Daniel, van Rheenen, Jacco, Krenning, Lenno, Medema, René H.
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998378/
https://ncbi.nlm.nih.gov/pubmed/33801903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10030610
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