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Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
Activation of the DNA-damage response can lead to the induction of an arrest at various stages in the cell cycle. These arrests are reversible in nature, unless the damage is too excessive. Here we find that checkpoint reversibility is lost in cells that are in very late G2, but not yet fully commit...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5007458/ https://ncbi.nlm.nih.gov/pubmed/27561326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12618 |
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