Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

We developed genetic-epigenetic tissue mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant wom...

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Foilsithe in:eLife
Main Authors: Gai, Wanxia, Zhou, Ze, Agbor-Enoh, Sean, Fan, Xiaodan, Lian, Sheng, Jiang, Peiyong, Cheng, Suk Hang, Wong, John, Chan, Stephen L, Jang, Moon Kyoo, Yang, Yanqin, Liang, Raymond HS, Chan, Wai Kong, Ma, Edmond SK, Leung, Tak Y, Chiu, Rossa WK, Valantine, Hannah, Chan, KC Allen, Lo, YM Dennis
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2021
Ábhair:
Medicine
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997656/
https://ncbi.nlm.nih.gov/pubmed/33752803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64356
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