Novel Antimalarial Tetrazoles and Amides Active Against the Hemoglobin Degradation Pathway in Plasmodium falciparum

Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to develop high-level resistance. Preliminary structure ac...

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發表在:J Med Chem
Main Authors: Lawong, Aloysus, Gahalawat, Suraksha, Okombo, John, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Deni, Ioanna, Bridgford, Jessica L., Niederstrasser, Hanspeter, Zhou, Anwu, Posner, Bruce, Wittlin, Sergio, Gamo, Francisco Javier, Crespo, Benigno, Churchyard, Alisje, Baum, Jake, Mittal, Nimisha, Winzeler, Elizabeth, Laleu, Benoît, Palmer, Michael J., Charman, Susan A., Fidock, David A., Ready, Joseph M., Phillips, Margaret A.
格式: Artigo
語言:Inglês
出版: 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997635/
https://ncbi.nlm.nih.gov/pubmed/33620219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02022
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