The intracellular domain of homomeric glycine receptors modulates agonist efficacy

Like other pentameric ligand-gated channels, glycine receptors (GlyRs) contain long intracellular domains (ICDs) between transmembrane helices 3 and 4. Structurally characterized GlyRs are generally engineered to have a very short ICD. We show here that for one such construct, zebrafish GlyR(EM), th...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Ivica, Josip, Lape, Remigijus, Jazbec, Vid, Yu, Jie, Zhu, Hongtao, Gouaux, Eric, Gold, Matthew G., Sivilotti, Lucia G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995613/
https://ncbi.nlm.nih.gov/pubmed/33617876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012358
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