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Openings of the Rat Recombinant α1 Homomeric Glycine Receptor as a Function of the Number of Agonist Molecules Bound

The functional properties of rat homomeric α1 glycine receptors were investigated using whole-cell and outside-out recording from human embryonic kidney cells transfected with rat α1 subunit cDNA. Whole-cell dose-response curves gave EC (50) estimates between 30 and 120 μM and a Hill slope of ∼3.3....

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Detalhes bibliográficos
Main Authors: Beato, Marco, Groot-Kormelink, Paul J., Colquhoun, David, Sivilotti, Lucia G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233816/
https://ncbi.nlm.nih.gov/pubmed/11981023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.20028530
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