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Single-channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit. This mutation reduces the sensitivity of the receptor to glycine, but the mechanism by which this...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Blackwell Science Inc
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075205/ https://ncbi.nlm.nih.gov/pubmed/17331994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.126920 |
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