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The α1K276E Startle Disease Mutation Reveals Multiple Intermediate States in the Gating of Glycine Receptors
Loss-of-function mutations in human glycine receptors cause hyperekplexia, a rare inherited disease associated with an exaggerated startle response. We have studied a human disease mutation in the M2–M3 loop of the glycine receptor α1 subunit (K276E) using direct fitting of mechanisms to single-chan...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6796251/ https://ncbi.nlm.nih.gov/pubmed/22279218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4346-11.2012 |
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