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The long activations of α2 glycine channels can be described by a mechanism with reaction intermediates (“flip”)

The α2 glycine receptor (GlyR) subunit, abundant in embryonic neurons, is replaced by α1 in the adult nervous system. The single-channel activity of homomeric α2 channels differs from that of α1-containing GlyRs, as even at the lowest glycine concentration (20 µM), openings occurred in long (>300...

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Detalhes bibliográficos
Main Authors: Krashia, Paraskevi, Lape, Remigijus, Lodesani, Francesco, Colquhoun, David, Sivilotti, Lucia G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032374/
https://ncbi.nlm.nih.gov/pubmed/21282399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010521
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