Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation

We have previously identified the natural product obtusaquinone (OBT) as a potent antineoplastic agent with promising in vivo activity in glioblastoma and breast cancer through the activation of oxidative stress; however, the molecular properties of this compound remained elusive. We used a multidis...

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Pubblicato in:ACS Chem Biol
Autori principali: Badr, Christian E., da Hora, Cintia Carla, Kirov, Aleksandar B., Tabet, Elie, Amante, Romain, Maksoud, Semer, Nibbs, Antoinette E., Fitzsimons, Evelyn, Boukhali, Myriam, Chen, John W., Chiu, Norman H. L., Nakano, Ichiro, Haas, Wilhelm, Mazitschek, Ralph, Tannous, Bakhos A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995447/
https://ncbi.nlm.nih.gov/pubmed/32338864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00104
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