Sustained NF-κB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition

Glioblastoma is an incurable and highly aggressive brain tumor. Understanding therapeutic resistance and survival mechanisms driving this tumor type is key to finding effective therapies. Smac mimetics (SM) emerged as attractive cancer therapeutics particularly for tumor populations that are highly...

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Publicado en:Cell Death Discov
Autores principales: da Hora, Cintia Carla, Pinkham, Kelsey, Carvalho, Litia, Zinter, Max, Tabet, Elie, Nakano, Ichiro, Tannous, Bakhos A., Badr, Christian E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399311/
https://ncbi.nlm.nih.gov/pubmed/30854231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-019-0155-9
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