Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation

We have previously identified the natural product obtusaquinone (OBT) as a potent antineoplastic agent with promising in vivo activity in glioblastoma and breast cancer through the activation of oxidative stress; however, the molecular properties of this compound remained elusive. We used a multidis...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Badr, Christian E., da Hora, Cintia Carla, Kirov, Aleksandar B., Tabet, Elie, Amante, Romain, Maksoud, Semer, Nibbs, Antoinette E., Fitzsimons, Evelyn, Boukhali, Myriam, Chen, John W., Chiu, Norman H. L., Nakano, Ichiro, Haas, Wilhelm, Mazitschek, Ralph, Tannous, Bakhos A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995447/
https://ncbi.nlm.nih.gov/pubmed/32338864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00104
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