MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis

Myeloid differentiation primary response protein 88 (MYD88) is a critical universal adapter that transduces signaling from Toll-like and interleukin receptors to downstream nuclear factor-κB (NF-κB). MYD88(L265P) (leucine changed to proline at position 265) is a gain-of-function mutation that occurs...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Yu, Xinfang, Li, Wei, Deng, Qipan, Liu, Haidan, Wang, Xu, Hu, Hui, Cao, Ya, Xu-Monette, Zijun Y., Li, Ling, Zhang, Mingzhi, Lu, Zhongxin, Young, Ken H., Li, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995293/
https://ncbi.nlm.nih.gov/pubmed/33025009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020004918
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