Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Plasma low-density lipoprotein (LDL) is primarily cleared by LDL receptor (LDLR). LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into extracellular milieu. However, the proteinase responsible for LDLR cleavage is unknown. Here we report that membrane type 1-matrix meta...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Alabi, Adekunle, Xia, Xiao-Dan, Gu, Hong-Mei, Wang, Faqi, Deng, Shi-Jun, Yang, Nana, Adijiang, Ayinuer, Douglas, Donna N., Kneteman, Norman M., Xue, Yazhuo, Chen, Li, Qin, Shucun, Wang, Guiqing, Zhang, Da-Wei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994674/
https://ncbi.nlm.nih.gov/pubmed/33767172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22167-3
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