Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth factor precursor homology repeat-A of LDLR, at least...

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Bibliografiska uppgifter
I publikationen:J Lipid Res
Huvudupphovsmän: Deng, Shi-jun, Alabi, Adekunle, Gu, Hong-mei, Adijiang, Ayinuer, Qin, Shucun, Zhang, Da-wei
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399494/
https://ncbi.nlm.nih.gov/pubmed/30617148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M089193
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