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Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth factor precursor homology repeat-A of LDLR, at least...
Guardat en:
| Publicat a: | J Lipid Res |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Biochemistry and Molecular Biology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6399494/ https://ncbi.nlm.nih.gov/pubmed/30617148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M089193 |
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