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Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth factor precursor homology repeat-A of LDLR, at least...
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| Publicado no: | J Lipid Res |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6399494/ https://ncbi.nlm.nih.gov/pubmed/30617148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M089193 |
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