Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Plasma low-density lipoprotein (LDL) is primarily cleared by LDL receptor (LDLR). LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into extracellular milieu. However, the proteinase responsible for LDLR cleavage is unknown. Here we report that membrane type 1-matrix meta...

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Vydáno v:Nat Commun
Hlavní autoři: Alabi, Adekunle, Xia, Xiao-Dan, Gu, Hong-Mei, Wang, Faqi, Deng, Shi-Jun, Yang, Nana, Adijiang, Ayinuer, Douglas, Donna N., Kneteman, Norman M., Xue, Yazhuo, Chen, Li, Qin, Shucun, Wang, Guiqing, Zhang, Da-Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994674/
https://ncbi.nlm.nih.gov/pubmed/33767172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22167-3
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