Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Plasma low-density lipoprotein (LDL) is primarily cleared by LDL receptor (LDLR). LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into extracellular milieu. However, the proteinase responsible for LDLR cleavage is unknown. Here we report that membrane type 1-matrix meta...

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Publicat a:Nat Commun
Autors principals: Alabi, Adekunle, Xia, Xiao-Dan, Gu, Hong-Mei, Wang, Faqi, Deng, Shi-Jun, Yang, Nana, Adijiang, Ayinuer, Douglas, Donna N., Kneteman, Norman M., Xue, Yazhuo, Chen, Li, Qin, Shucun, Wang, Guiqing, Zhang, Da-Wei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994674/
https://ncbi.nlm.nih.gov/pubmed/33767172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22167-3
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