Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery, chemotherapy and, if age permits, radiotherapy), median survival is 17 months(1,2). We show that ATRTs robustly express B7-H3...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Theruvath, Johanna, Sotillo, Elena, Mount, Christopher W., Graef, Claus Moritz, Delaidelli, Alberto, Heitzeneder, Sabine, Labanieh, Louai, Dhingra, Shaurya, Leruste, Amaury, Majzner, Robbie G., Xu, Peng, Mueller, Sabine, Yecies, Derek W., Finetti, Martina A., Williamson, Daniel, Johann, Pascal D., Kool, Marcel, Pfister, Stefan, Hasselblatt, Martin, Frühwald, Michael C., Delattre, Olivier, Surdez, Didier, Bourdeaut, Franck, Puget, Stephanie, Zaidi, Sakina, Mitra, Siddhartha S., Cheshier, Samuel, Sorensen, Poul H., Monje, Michelle, Mackall, Crystal L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992505/
https://ncbi.nlm.nih.gov/pubmed/32341579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0821-8
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