HIF1α/HIF2α–Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR–PI3K/AKT signalling pathway with positive feedback under hypoxia

Previous studies have suggested that hypoxic responses are regulated by hypoxia-inducible factors (HIFs), which in turn promote the malignant progression of glioblastoma (GBM) by inhibiting apoptosis and increasing proliferation; these events lead to a poor prognosis of GBM patients. However, there...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Wang, Pan, Zhao, Lu, Gong, Sheng, Xiong, Shuanglong, Wang, Junwei, Zou, Dewei, Pan, Jinyu, Deng, Yangmin, Yan, Qian, Wu, Nan, Liao, Bin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990922/
https://ncbi.nlm.nih.gov/pubmed/33762574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03598-8
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