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HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

Chemotherapy plays a significant role in glioma treatment; however, it has limited effectiveness in extending the life expectancies of glioma patients. Traditional studies have attributed this lack of efficacy to glioma stem cells (GSCs) and their high resistance to chemotherapy, and hypoxia worsens...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Wang, Pan, Wan, Wenwu, Xiong, Shuanglong, Wang, Junwei, Zou, Dewei, Lan, Chuan, Yu, Shuangjiang, Liao, Bin, Feng, Hua, Wu, Nan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554160/
https://ncbi.nlm.nih.gov/pubmed/28801626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06086-2
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