Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

TUG proteins bind and sequester GLUT4 glucose transporters intracellularly, and insulin stimulates TUG cleavage to translocate this GLUT4 to the cell surface and increase glucose uptake. This effect of insulin is independent of phosphatidylinositol-3-kinase, and its physiological relevance remains u...

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Publicado no:Nat Metab
Main Authors: Habtemichael, Estifanos N., Li, Don T., Camporez, João Paulo, Westergaard, Xavier O., Sales, Chloe I., Liu, Xinran, López-Giráldez, Francesc, DeVries, Stephen G., Li, Hanbing, Ruiz, Diana M., Wang, Kenny Y., Sayal, Bhavesh S., Zapata, Sofia González, Dann, Pamela, Brown, Stacey N., Hirabara, Sandro, Vatner, Daniel F., Goedeke, Leigh, Philbrick, William, Shulman, Gerald I., Bogan, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990718/
https://ncbi.nlm.nih.gov/pubmed/33686286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-021-00359-x
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