Disease-linked supertrafficking of a potassium channel

Gain-of-function (GOF) mutations in the voltage-gated potassium channel subfamily Q member 1 (KCNQ1) can induce cardiac arrhythmia. In this study, it was tested whether any of the known human GOF disease mutations in KCNQ1 act by increasing the amount of KCNQ1 that reaches the cell surface—“supertra...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Huang, Hui, Chamness, Laura M., Vanoye, Carlos G., Kuenze, Georg, Meiler, Jens, George, Alfred L., Schlebach, Jonathan Patrick, Sanders, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988323/
https://ncbi.nlm.nih.gov/pubmed/33600800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100423
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