Disease-linked supertrafficking of a potassium channel

Gain-of-function (GOF) mutations in the voltage-gated potassium channel subfamily Q member 1 (KCNQ1) can induce cardiac arrhythmia. In this study, it was tested whether any of the known human GOF disease mutations in KCNQ1 act by increasing the amount of KCNQ1 that reaches the cell surface—“supertra...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Huang, Hui, Chamness, Laura M., Vanoye, Carlos G., Kuenze, Georg, Meiler, Jens, George, Alfred L., Schlebach, Jonathan Patrick, Sanders, Charles R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988323/
https://ncbi.nlm.nih.gov/pubmed/33600800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100423
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