Disease-linked supertrafficking of a potassium channel

Gain-of-function (GOF) mutations in the voltage-gated potassium channel subfamily Q member 1 (KCNQ1) can induce cardiac arrhythmia. In this study, it was tested whether any of the known human GOF disease mutations in KCNQ1 act by increasing the amount of KCNQ1 that reaches the cell surface—“supertra...

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Udgivet i:J Biol Chem
Main Authors: Huang, Hui, Chamness, Laura M., Vanoye, Carlos G., Kuenze, Georg, Meiler, Jens, George, Alfred L., Schlebach, Jonathan Patrick, Sanders, Charles R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988323/
https://ncbi.nlm.nih.gov/pubmed/33600800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100423
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