Disease-linked supertrafficking of a potassium channel

Gain-of-function (GOF) mutations in the voltage-gated potassium channel subfamily Q member 1 (KCNQ1) can induce cardiac arrhythmia. In this study, it was tested whether any of the known human GOF disease mutations in KCNQ1 act by increasing the amount of KCNQ1 that reaches the cell surface—“supertra...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Huang, Hui, Chamness, Laura M., Vanoye, Carlos G., Kuenze, Georg, Meiler, Jens, George, Alfred L., Schlebach, Jonathan Patrick, Sanders, Charles R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988323/
https://ncbi.nlm.nih.gov/pubmed/33600800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100423
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