Crowded Organelles, Lipid Accumulation, and Abnormal Membrane Tubulation in Cellular Models of Enhanced α-Synuclein Membrane Interaction

Previous work from our group showed that certain engineered missense mutations to the α-synuclein (αS) KTKEGV repeat motifs abrogate the protein’s ability to form native multimers. The resultant excess monomers accumulate in lipid membrane-rich inclusions associated with neurotoxicity exceeding that...

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Bibliographic Details
Published in:Brain Res
Main Authors: Ericsson, Maria, von Saucken, Victoria, Newman, Andrew, Doehr, Lena, Hoesch, Camilla, Kim, Tae-Eun, Dettmer, Ulf
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988302/
https://ncbi.nlm.nih.gov/pubmed/33571519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2021.147349
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